The Center for Stem Cell Research & Application is a newly established one in 2011.The center mainly focus on uncovering mechanisms controlling human pluripotent stem cell (hPSCs, including hESC and hiPSCs) to differentiate into functionally mature hematopoietic cells and exploring the possibility of clinical applications. We also develop methods for efficiently reprogramming human peripheral / umbilical cord blood cells into hiPSCs. We are now fucusing on the following research:1) hPSC-derived hematopoietic stem / progenitor cells. 2)Molecular control of early human hematopoiesis by using hPSC as the model. 3) hPSC-derived erythrocytes as transfusion substitute. 4) hPSC-derived early innate immune cells and their functions. 5) Analysis of diseased hematopoiesis by using patient-specific iPSCs as the model.
Recently, we have successfully gained various grant support from government, such as “973 Project” and National Natural Science Foundation of China, etc. We cooperate with many other institutes and universities such as State Key Lab of Experimental Hematology (Tianjin), Institute of Basic Medical Sciences, Zhejiang University, and set several joint laboratories with companies to develop possibe clinical applications. With 16 staffs, including 2 senior engineers and 12 masters and doctors, we have published more than 26 papers in recent years.
We are interested in research on induction of hPSCs to functionally mature blood cells (erythrocytes, eosinophils, macrophages and mast cells, etc) and their possible applications. We are also interested in establishing high efficient methods to reprogram a small amount human peripheral / umbilical cord blood cells into hiPSCs and developing diseased models.We are exploring the method to induce mature blood cells in whole humanized system and uncovering mechanisms controlling early hematopoiesis through regulating genes and small molecules.
PI簡介
馬 峰
1983年本科畢業于南京醫科大學，1992年碩士畢業于蘇州大學醫學院，2000年博士畢業于東京大學；1991－1992年，衛生部笹川獎學金研修生公派赴日（日本國信州大學）1996－1997年 衛生部笹川獎學金特別研究員公派赴日（日本國信州大學）1998-2000年 日本學術振興會博士后特別研究員（東京大學）2000-2003年 日本國東京大學醫科學研究所博士后研究員2003－2006年 日本國京都大學大學院醫學研究科助理教授。2006－2010年 日本國東京大學醫科學研究所助理教授2011－中國醫學科學院輸血研究所干細胞研究中心主任、中國醫科學院北京協和醫學院特聘教授 ，2012－中國醫學科學院輸血研究所副所長（分管科研）。長期從事造血干細胞和人類ES/iPS細胞向造血細胞誘導分化的基礎與臨床應用研究。在人類ES/iPS細胞向紅細胞以及自然免疫相關細胞等功能成熟血細胞的分化發育方面有創新成績。Tel：+86-28-61648510 Email：mafeng@hotmail.co.jp
Dr. Feng Ma, Stem Cell Biologist and Pediatric Hematologist, graduated from Nanjing Medical University in 1983, he worked as a pediatrician at Zhenjiang No.1 Hospital from 1983 to 1988. Since then, he had been working at the Children’s Hospital of Suzhou University and got his Master Degree in Medical Science in 1994. He first went to Japan in 1991 for one-year research on hematopoiesis and again to Japan in 1996 (Both by Sasakawa Medical Foundation, Department of Public Health of China). He gained his PhD Degree in Medical Science at the University of Tokyo in 2000. After then, he has been serving as a Postdoctoral Research Fellow, and then an Assistant Professor, at the Institute of Medical Science, University of Tokyo and Kyoto University.
Dr. Ma’s recent main research is focusing on hESC / hiPSC-derived hematopoietic cells and their possible use in clinical applications. He is currently a Professor of the CAMS & PUMC and the Executive Director of the Institute of Blood Transfusion, CAMS.
苑宇哲
中國醫學科學院輸血研究所，副研究員。2008年獲中國科學院動物研究所理學博士，于同年至中國醫學科學院輸血研究所工作。研究內容：生物信息學的深度測序的數據分析及應用。
通過對血液循環中的DNA，血液中病原體，干細胞的風險因子，血液的干紙板等對象的監測，從而獲得細胞轉化的marker（相關于癌癥發生），外源性病毒，內源性病毒，細菌感染，支原體感染，未知新發病毒體因子，從而為輸血醫學提供基礎醫學理論支持。
E-mail: yuzhe.yuan@gmail.com
Yuan, Yuzhe
2008.11, Ph. D. in science Institute of Zoology Chinese Academy of Science, China. 2008.11-present Research Associate Institute of blood transfusion Chinese Academy of Medical Sciences, China
Research Area
Bioinformatics Data analysis and application of deep sequencing
This research area focus on monitoring DNA and pathogens in blood circulation, risk factors in stem cells and dried cardboard of blood, in order to get marker of cell transformation (related to cancer), and information of exogenous virus, endogenous virus, bacterial infections, mycoplasma infection and unknown emerging virions. This research work will provide basic medical theory support to transfusion medicine.
