陳波—副研究員

                                                                      
       陳波，1976年生，武漢大學生命科學學院獲得理學碩士學位，中國科學院水生生物系研究所理學博士學位，副研究員，碩士生導師。2007年至2013年期間在美國進行訪問學者和博士后研究，先后在佛羅里達國際大學化學及生物化學系、貝勒醫學院分子及人類遺傳學系、亞拉巴馬大學伯明翰分校生物化學和分子遺傳學系UAB干細胞研究所等地進行分子遺傳學，醫學遺傳學以及干細胞生物學的研究。
主要從事造血干細胞及造血分化過程分子調控機制研究。運用分子遺傳學手段在人類胚胎干細胞共培養體系中研究人類造血發生過程中的分子調控機制。已經和正在建立一系列重要造血相關基因過表達或沉默的多能干細胞系，試圖通過調控這些基因的表達來干擾造血分化進程，摸索最優的誘導分化模式，并發現新的造血相關基因。同時開展細胞治療和基因治療的研究，正在嘗試建立一套比較完整基于MSC和CART的基因治療載體系統和相應的腫瘤治療動物模型，為未來基因治療/細胞免疫治療/干細胞治療搭建通用平臺。至今已在多種國際雜志上發表各類論文30篇，其中SCI論文24篇，引用600余次。
 
研究方向
       造血干細胞及造血分化過程分子調控機制研究，基因治療/細胞免疫治療/干細胞治療
 
社會任職及榮譽
       四川省細胞生物學會，理事，2016.4-至今
 
承擔科研項目情況

1. 四川省科技廳，四川省科技廳青年項目：“基因原位置換技術調控Gata1在hESC向造血細胞分化過程的時序表達特性” , 2014JQ0058，，第一主持人，2014.01-2016.12
2. 四川省科技廳，四川省重點研發（省院省?？萍己献鳎╉椖浚?ldquo;納米材料培養胚胎干細胞提升造血分化潛能的應用及理論研究”， 2020YFSY0023，第一主持人，2020.01-2021.12

　　
代表論著
       著作
Chen B, Mao B, Huang S, Zhou Y, Tsuji K and Ma F. 2014, Human Embryonic Stem Cell-Derived Primitive and Definitive Hematopoiesis.  Intech, Pluripotent Stem Cell Biology - Advances in Mechanisms, Methods and Models, July 2, Chapter4: 87-113. http://dx.doi.org/10.5772/58628
　　
       代表性論文

1. Sun W#, Yi D#, Zhu L#, Zeng J, Liu Y, Chang J, Teng J, Zhang Y, Dong Y, Pan X, Chen Y, Zhou Y, Lai M, Zhou Q, Liu J, Chen B*, Ma F*. 2021. RUNX1 overexpression triggered TGF-β signaling to upregulate p15 so as to block early hematopoiesis by inducing cell cycle arrest. Stem cell research. April. 2022, 60: 102694.  https://doi.org/10.1016/j.scr.2022.102694 (corresponding author) 
2. Yi D#, Zhu L#, Liu Y#, Zeng J, Chang J, Sun W, Teng J, Zhang Y, Dong Y, Pan X, Chen Y, Zhou Y, Lai M, Zhou Q, Liu J, Chen B*, Ma F*. Dec. 2021. The distinct effects of P18 overexpression on different stages of hematopoiesis involve TGF-β and NF-κB signaling. Scientific reports. 11: 24014. https://doi.org/10.1038/s41598-021-03263-2 (corresponding author) 
3. Lin J#, Zeng J#, Sun W#, Liu K, Enkhbat M, Yi D, Harati J, Liu J, Kingshott P, Chen Bo*, Ma F* and Wang PY*. Colloidal Self-Assembled Patterns Maintain the Pluripotency and Promote the Hemopoietic Potential of Human Embryonic Stem Cells. Front. Cell Dev. Biol., Nov. 2021, 9:771773. https://doi.org/10.3389/fcell.2021.771773 (Corresponding author)
4. Zeng J#, Yi D#, Sun W#, Liu Y, Chang J, Zhu L, Zhang Y, Pan X, Dong Y, Zhou Y, Lai M, Bian G, Zhou Q, Liu J, Chen B*, and Ma F* Overexpression of HOXA9 upregulates NF-κB signaling to promote human hematopoiesis and alter the hematopoietic differentiation potentials. Cell Regeneration. Jan 2021,10: 9-21. https://doi.org/10.1186/s13619-020-00066-0 (Co-corresponding author)
5. Zeng J#, Sun W#, Chang J, Yi D, Zhu L, Zhang Y, Pan X, Zhou Y, Lai M, Bian G, Zhou Q, Liu J, Chen B*, and Ma F*.  HOXC4 up-regulates NF-κB signaling and promotes the cell proliferation to drive development of human hematopoiesis, especially CD43+ cells. Blood Science. October 2020: 2, 117-128.http://dx.doi.org/10.1097/BS9.0000000000000054 (Corresponding author)
6. Zeng, J., Zhang, H., Liu, Y., Sun, W., Yi, D., Zhu, L., Zhang, Y., Pan, X., Chen, Y., Zhou, Y., Bian, G., Lai, M., Zhou, Q., Liu, J., Chen, B.*, Ma,F.*.. Overexpression of P21 Has Inhibitory Effect on Human Hematopoiesis by Blocking Generation of CD43＋ Cells via Cell-Cycle Regulation. International Journal of Stem Cells, June 2020, 13(2): 202-211. https://doi.org/10.15283/ijsc20033（Corresponding author）
7. Sun, W#., Zeng, J#., Chang, J#., Xue, Y., Zhang, Y., Pan, X., Zhou, Y., Lai, M., Bian, G., Zhou, Q., Liu, J., Chen, B*., Ma, F*. RUNX1-205, a novel splice variant of the human RUNX1 gene, has blockage effect on mesoderm–hemogenesis transition and promotion effect during the late stage of hematopoiesis， J. of Mol. Cell Biol.，May 2020, 12(5):386-96.https://doi.org/10.1093/jmcb/mjaa019 (Corresponding author)
8. Zhou, Y., Zhang, Y*., Chen, B., Dong, Y., Mao, B., Pan, X., Lai, M., Chen, Y., Bian, G., Zhou, Q., Nakahata, T., Zhou, J., Wu, M., Ma, F.  Overexpression of GATA2 Enhances Development and Maintenance of Human Embryonic Stem Cell-Derived Hematopoietic Stem Cell-like Progenitors. Stem cell reports, j July 9, 2019, 13: 31-47 https://doi.org/10.1016/j.stemcr.2019.05.007（3^rd author）.
9. Sun W#, Teng J#, Zeng J, Xue Y, Zhang Y, Pan X, Zhou Y, Lai M, Bian G, Zhou, Q., Liu, J., Chen, B*., Ma, F*. The piggyBac-based double-inducible vector system: A novel universal platform for studying gene functions and interactions.  Plasmid, Sept, 2019, 105: 102420-102425.https://doi.org/10.1016/j.plasmid.2019.102420. (Corresponding author)
10. Chang J#, Sun W#, Zeng J, Xue Y, Zhang Y, Pan X, Zhou Y, Lai M, Bian G, Zhou Q, Liu J, Chen B*, Guo F*, Ma F*. Establishment of an in vitro system based on AGM-S3 co-culture for screening traditional herbal medicines that stimulate hematopoiesis, Journal of Ethnopharmacology, August 10, 2019, 240: 111938-111944 doi: https://doi.org/10.1016/j.jep.2019.111938. (Corresponding author）
11. Chen B#, Teng J#, Liu H, Pan X, Zhou Y, Huang S, Lai M, Bian G, Mao B, Sun W, Zhou Q, Yang S, Nakahata T, and Ma F*, Sept 2017. Inducible Overexpression of RUNX1b/c in Human Embryonic Stem Cells Blocks Early Hematopoiesis from Mesoderm.  J. of Mol. Cell Biol.,9(4), 262–273. https://doi.org/10.1093/jmcb/mjx032 (First author)
12. Leng F, Chen B, Dunlap DD, 2011. Dividing a supercoiled DNA molecule into two independent topological domains. Proc. Natl. Acad. Sci. U. S. A, Dec 108(50): 19973–19978 (2^nd author)
13. Chen B, Xiao YZ, Liu C, Li CZ, Leng FF, 2010. DNA linking number change induced by sequence-specific DNA binding proteins. Nucleic Acids Research, Feb, 38(11): 3643-54(First author)
14. Chen B, Jasmine Y, Leng FF, 2010. DNA bending by the mammalian high mobility group protein AT Hook 2. Biochemistry, March.49 (8):1590-5. (First author)

專利

1. 帶有標記基因的Tet-on誘導過表達的重組載體及構建方法，專利號：ZL 2016 1 0552748.1
2. 構建Doxycycline/Mifepristone誘導過表達的帶有熒光蛋白標記基因的雙誘導表達載體，申請號/專利號：ZL 201910344079.2

 
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